Behavioral phenotyping



Service MBPF, Helsinki Phenotyping center, Kuopio
A1 Motor tests    
Automated monitoring of spontaneous activity x x
Rotarod x x
Beam walking x x
Catwalk   x
Grid hanging x  x
Grip strength x  
Cylinder test x x
Turning preference   x
Sensorimotor reflexes x x
A2 Sensory tests
Nociception (hotplate, tail flick) x x
Tactile sensitivity (von Frey Hairs) x x
Hearing (acoustic startle + prepulse inhibition) x x
Vision (visual discrimination) x x
Olfaction (olfactory threshold, discrimination) x x
A3 Emotion tests
Elevated plus-maze x x
Elevated zero-maze x
Light-dark box x x
Open field x x
Marble burying x x
CO2 panic test x
Forced swimming test x x
Tail suspension test x x
Sucrose preference x x
Fear conditioning x x
Novelty-suppressed feeding x x
Stress-induced hyperthermia x x
A4 Tests for addiction
Ethanol preference x x
Ethanol tolerance x
Conditioned place preference x x
Conditioned taste preference
A5 Social behavior
Social interaction x x
Sociability x x
Social dominance (tube test) x x
Territorial aggression x
Ultrasonic vocalisations x
A6 Cognitive tests
Short-term memory spontaneous alternation in T- or Y-mazes;
rewarded delayed alternation in T-maze;
working memory test in 8-arm radial maze; novel object recognition
x x
Long-term memory spatial navigation in ‘water maze’ (Morris swim task);
spatial navigation in Barnes maze; position preference in the T-maze;
long-term memory version of the 8-arm radial maze; fear conditioning; novel object recognition; odor discrimination
x x
Cognitive flexibility position reversal in the T-maze; new platform position in Morris swim task x x
Planning (nest building) x x
A7 Long-term monitoring
Spontaneous (circadian) activity in home-cage, single-housed animal x
Spontaneous activity and cognitive testing in social home-cage (IntelliCage) x
Metabolic phenotyping (activity, food/water intake, indirect calorimetry) x